Allison B. Herman

Dissociated adult mouse sinoatrial node cultures stay spontaneously electrically active beyond ten days on MEA arrays and, on compliant hydrogels, permit live tracking of heterogeneous S100B-EGFP-labeled cells.

SenCat catalogs senescence markers across 14 human cell types using transcriptomic and proteomic profiling, revealing shared metabolic pathways and enabling machine learning-based identification of senescent cells.

Single-cell aortic transcriptomics and plasma bioassays in aged mice show that intermittent fisetin treatment clears senescent endothelial cells and reverses endothelial dysfunction partially driven by circulating CXCL12.