Krystyna Mazan-Mamczarz

The paper identifies LANCL1-AS1 as a lncRNA that declines with age in human skeletal muscle, reduces mitochondrial activity, and impairs myogenesis by shortening mt-mRNA poly(A) tails.

SenCat catalogs senescence markers across 14 human cell types using transcriptomic and proteomic profiling, revealing shared metabolic pathways and enabling machine learning-based identification of senescent cells.

Single-cell aortic transcriptomics and plasma bioassays in aged mice show that intermittent fisetin treatment clears senescent endothelial cells and reverses endothelial dysfunction partially driven by circulating CXCL12.

The paper investigates the molecular interactome of HNRNPU, revealing its role in neuronal differentiation and DNA methylation through integration of PPI, RNA targets, and methylation data.