Myriam Gorospe

This study identifies CD4+ cytotoxic T cells in the bone marrow that enhance granulopoiesis in aged mice, contributing to age-related diseases and showing that CCR5 inhibition can mitigate these effects.

The paper identifies LANCL1-AS1 as a lncRNA that declines with age in human skeletal muscle, reduces mitochondrial activity, and impairs myogenesis by shortening mt-mRNA poly(A) tails.

SenCat catalogs senescence markers across 14 human cell types using transcriptomic and proteomic profiling, revealing shared metabolic pathways and enabling machine learning-based identification of senescent cells.

Single-cell aortic transcriptomics and plasma bioassays in aged mice show that intermittent fisetin treatment clears senescent endothelial cells and reverses endothelial dysfunction partially driven by circulating CXCL12.

The paper investigates the molecular interactome of HNRNPU, revealing its role in neuronal differentiation and DNA methylation through integration of PPI, RNA targets, and methylation data.

The paper shows that TRF1 loss in MEFs triggers inflammation via ATR/cGAS/STING and ATM/STING pathways by inducing DNA damage and cytosolic DNA.

The paper investigates how senescence affects the integrated stress response and secretory phenotype in human cells, finding that translational repression of ATF4 reduces stress response and enhances inflammation.

This study finds that blood mitochondrial DNA copy number is consistently associated with personality traits and mediates the link between personality and mortality in two genetic cohorts.

The paper identifies circRNAs from synaptic host genes in human neuronal differentiation and shows SFPQ regulates their expression.