Rachel B. Munk

The paper identifies LANCL1-AS1 as a lncRNA that declines with age in human skeletal muscle, reduces mitochondrial activity, and impairs myogenesis by shortening mt-mRNA poly(A) tails.

SenCat catalogs senescence markers across 14 human cell types using transcriptomic and proteomic profiling, revealing shared metabolic pathways and enabling machine learning-based identification of senescent cells.

Single-cell aortic transcriptomics and plasma bioassays in aged mice show that intermittent fisetin treatment clears senescent endothelial cells and reverses endothelial dysfunction partially driven by circulating CXCL12.

This study shows that DNA hydroxymethylation in gene bodies limits transcriptional changes with age in mouse and human tissues.

The paper investigates how senescence affects the integrated stress response and secretory phenotype in human cells, finding that translational repression of ATF4 reduces stress response and enhances inflammation.