Genetic & Genomic MedicinemedRxivPreprint
Ancestry Calibration of Polygenic Risk Scores Improves Risk Stratification and Effect Estimation in African American Adults
Luciana B. Vargas, Mariah Meyer, Iain R. Konigsberg…·Ethan M. Lange
This study calibrates polygenic risk scores (PRS) for African American adults based on genetic ancestry, improving risk stratification and effect estimation for type 2 diabetes and height.