Ethan M. Lange

Bone response to intermittent parathyroid hormone (PTH) is both genetic and sex specific

This study investigates genetic and sex-specific factors influencing bone response to PTH in mice, finding strong heritability and sex-dependent mechanisms.

An Efficient Lasso Framework for Admixture-Aware Polygenic Scores

HAUDI improves polygenic score construction for admixed populations by efficiently extending the GAUDI method to multi-way admixture with faster computation and better performance.

Genome-wide association study provides novel insight into the genetic architecture of severe obesity.

This study identifies novel genetic signals associated with severe obesity through GWAS and shows strong genetic overlap with BMI, highlighting shared comorbidities and lifestyle interactions.

Modeling the genomic architecture of adiposity and anthropometrics across the lifespan

This study models the genomic architecture of adiposity and anthropometrics across the lifespan, identifying shared and distinct genetic factors and their associations with health outcomes.

Ancestry Calibration of Polygenic Risk Scores Improves Risk Stratification and Effect Estimation in African American Adults

This study calibrates polygenic risk scores (PRS) for African American adults based on genetic ancestry, improving risk stratification and effect estimation for type 2 diabetes and height.

A rapid, accurate approach to inferring pedigrees in endogamous populations

This paper introduces a rapid algorithm for pedigree inference in endogamous populations, accurately distinguishing relationships and handling reticulations.

Characterizing substructure via mixture modeling in large-scale genetic summary statistics

Summix2 uses mixture modeling to estimate and adjust for substructure in genetic summary data, improving the robustness and equity of research using diverse datasets.

Epigenome-wide association study meta-analysis of BMI in African American Adults

This study conducts an epigenome-wide association study (EWAS) meta-analysis of BMI in African American adults, identifying 208 significant CpGs and 54 DMRs associated with BMI, including novel and replicated findings.

Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations

Admix-kit provides tools for genetic analysis of admixed populations, enabling simulation, association testing, and polygenic scoring.

Strong protective effect of the APOL1 p.N264K variant against G2-associated FSGS and kidney disease

The paper shows the APOL1 p.N264K variant reduces the risk of FSGS and kidney disease in individuals with G2 APOL1 risk alleles.

Recovery of trait heritability from whole genome sequence data

The paper estimates heritability for height and BMI using whole-genome sequence data and finds that rare variants contribute significantly to the missing heritability.

Protein prediction for trait mapping in diverse populations

The paper develops genetic predictors of plasma protein abundance in diverse populations and demonstrates their utility in proteome-wide association studies (PWAS) for complex traits.

Population Stratification at the Phenotypic Variance level and Implication for the Analysis of Whole Genome Sequencing Data from Multiple Studies

The paper addresses variance stratification in pooled whole genome sequencing data, showing how study-specific phenotypic variances affect analysis and introducing a method to improve statistical power and reduce false positives.

Genome-wide association study of asthma in individuals of African ancestry reveals novel asthma susceptibility loci

This study identifies novel asthma susceptibility loci in individuals of African ancestry through genome-wide association analysis and admixture mapping.