Luciana B. Vargas

Genetics in Context: Social Factors Modify Polygenic Risk Across Multiple Cardiometabolic Diseases

The paper examines how social determinants of health modify polygenic risk scores for cardiometabolic diseases and shows that integrating social and genetic factors improves disease prediction.

Modeling the genomic architecture of adiposity and anthropometrics across the lifespan

This study models the genomic architecture of adiposity and anthropometrics across the lifespan, identifying shared and distinct genetic factors and their associations with health outcomes.

Ancestry Calibration of Polygenic Risk Scores Improves Risk Stratification and Effect Estimation in African American Adults

This study calibrates polygenic risk scores (PRS) for African American adults based on genetic ancestry, improving risk stratification and effect estimation for type 2 diabetes and height.

Characterizing substructure via mixture modeling in large-scale genetic summary statistics

Summix2 uses mixture modeling to estimate and adjust for substructure in genetic summary data, improving the robustness and equity of research using diverse datasets.

Proteomic Networks and Related Genetic Variants Associated with Smoking and Chronic Obstructive Pulmonary Disease

The paper identifies proteomic networks and genetic variants associated with smoking and COPD phenotypes using multi-ethnic proteomic data and network-based GWAS.