Wenxue Li

This study introduces a robust multiplex DIA-MS workflow with machine learning and statistical filtering to profile protein turnover in cisplatin-resistant cancer cells, revealing correlations between transcript regulation and protein degradation.

The paper introduces DeltaSILAC, a proteomic method to quantify how phosphorylation affects protein endurance in cancer cells, revealing its global impact on protein turnover and identifying sequence features associated with endurance changes.