Role of AMPK in Atrial Metabolic Homeostasis and Substrate Preference
Zeren Toksoy, Yina Ma, Leigh Goedeke, Wenxue Li, Xiaoyue Hu, Xiaohong Wu, Marine Cacheux, Yansheng Liu, Fadi G. Akar, Gerald I. Shulman, Lawrence H. Young
This study shows that atrial AMPK deletion shifts metabolism from fatty acid oxidation to pyruvate oxidation and disrupts metabolic pathways, contributing to atrial remodeling and arrhythmia.
bioRxiv · Aug 29, 2024 · PreprintPhysiology