Igor dos Santos Cestari

The paper identifies a yeast-based therapeutic vaccine candidate for chronic Chagas disease by screening T. cruzi antigens with patient antibodies and validating its efficacy in mice.

This study shows that chromosome compartment assembly is essential for subtelomeric gene silencing in Trypanosoma brucei, with RAP1 and phosphoinositides regulating this process.

This study shows stochastic variation in virulence gene expression in T. cruzi helps diversify infection and evade immune recognition.

This paper presents an optimized electroporation protocol for high-efficiency yeast transformation, enabling efficient expression of whole-genome libraries with minimal DNA input.