Author

Claudia A. Doege

Columbia University Irving Medical CenterORCID 0000-0003-3871-4765Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetic & Genomic Medicine· 1 Genetics· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 4 Research Focus:gene regulatory network inference· 2 Research Focus:GWAS / association mapping· 2 Assay:whole-exome sequencing· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Alessandra ChesiiD· 2 shared Hannah J. GloveriD· 2 shared Rudolph L. LeibeliD· 2 shared Struan F.A. GrantiD· 2 shared Alisha Basak· 1 shared Andrew D. WellsiD· 1 shared Anton M. SimeonoviD· 1 shared Aparna BhaduriiD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersGenomics

Alessandra ChesiORCID

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Author profile →

5 papers

Recent·Most cited

Developmental BiologyStem Cell ReportsPeer-reviewedJun 11, 2026

Scalable Hypothalamic Arcuate Neuron Differentiation from Human Pluripotent Stem Cells Suitable for Modeling Metabolic and Reproductive Disorders

Vukasin M. Jovanovic, Narisu Narisu, Lori L. Bonnycastle…·Carlos A. Tristan

This paper describes a scalable method to differentiate human pluripotent stem cells into hypothalamic arcuate neurons, which can model metabolic and reproductive disorders.

DOI 10.1016/j.stemcr.2026.102958

humanATAC-seq

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NeuroscienceScience AdvancesPeer-reviewedNov 8, 2023

Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus

Brian R. Herb, Hannah J. Glover, Aparna Bhaduri…·Seth A. Ament

The paper uses single-cell genomics to reconstruct developmental trajectories of 170 neuronal subtypes in the human hypothalamus across development.

56 citationstop 3%

humanmouse

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Genetic & Genomic MedicinemedRxivPreprintFeb 19, 2023

Predicted loss of function alleles in Bassoon (BSN) are associated with obesity

Na Zhu, Charles A. LeDuc, Ilene Fennoy…·Rudolph L. Leibel

The paper identifies rare heterozygous predicted loss of function variants in BSN associated with higher BMI in multiple cohorts.

DOI 10.1101/2023.02.19.23285978

humanwhole-exome sequencing

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GenomicsNature CommunicationsPeer-reviewedNov 19, 2021

Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant common complex traits

Matthew C. Pahl, Claudia A. Doege, Kenyaita M. Hodge…·Struan F.A. Grant

The paper maps cis-regulatory elements in human ESC-derived hypothalamic neurons and links them to GWAS loci for complex traits, identifying candidate genes and regulatory elements involved in hypothalamic development.

46 citations

humanChIP-seq

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GeneticsbioRxivPreprintDec 10, 2018

Clinical and Functional Characterization of Melanocortin 4 Receptor genetic variants in African American and/or Hispanic children with severe early onset obesity.

Maria Cristina De Rosa, Alessandra Chesi, Shana Erin McCormack…·Vidhu Thaker

The paper identifies MC4R mutations in African American and Hispanic children with severe early onset obesity, finding a 2.6% prevalence and three novel variants.

DOI 10.1101/491969

humanwhole-exome sequencing

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