Aparna Bhaduri

PULSE, a foundation model trained on neural recordings, reveals how disease variants affect network development and how circuits encode information in brain organoids.

This study shows that exosomes mediate bidirectional signaling between glioma stem cells and non-stem cells, influencing their homeostasis and radiation-induced plasticity.

This study uses human cortical organoids to model radiation-induced neural injury and test mitigators, showing partial recovery and transcriptional changes with potential therapeutic interventions.

Reprocessing nine human brain datasets (2,157,582 cells, 156 donors, GW6 to adulthood) under one marker-based taxonomy yields 35 replicable cell types with cell type-specific timing of adult-like maturation.

This study shows that glutamatergic neuron-tumor synapses influence glioblastoma cell states by modulating radial glia plasticity and transcriptional programs.

The paper identifies YBX1 as a key transcription factor in shaping human prefrontal cortex molecular identity through CRISPR activation screens and organoid experiments.

This study identifies IL-6 as a driver of immunosuppression in glioblastoma, showing that its inhibition enhances response to immune checkpoint therapy and radiotherapy in preclinical models.

The paper maps clonal hierarchies in glioblastoma using lineage-resolved single-cell data, revealing multiple non-redundant progenitors and identifying cell type-specific therapeutic targets.

The paper uses a human organoid tumor transplantation system to study glioblastoma-microenvironment interactions, identifying PTPRZ1 as a key mediator of intercellular communication.

Autologous co-culture of patient glioblastoma cells and matched peripheral blood mononuclear cells in human cortical organoids (iHOTT) preserves tumor-immune crosstalk and recapitulates patient T cell responses to pembrolizumab.

This study uses human brain organoids to show that glioblastoma cells adopt neuron-like states and interact with region-specific synaptic inputs to drive invasion.

This study shows that prenatal lead exposure biases neural cell fate in human brain development by increasing neurons and reducing astrocytes through epigenetic changes.

This study shows thalamic NRXN1 signaling promotes human cortical upper-layer neurogenesis by interacting with outer radial glia.

The paper integrates seven single-cell transcriptomic datasets to generate 225 meta-modules, identifying key gene networks involved in human cortical cell subtype specification and validating their roles in neurodevelopment.

The paper develops a novel urea-based compound, MXC-017, that crosses the blood-brain barrier, targets glioma stem cells, and improves survival in GBM models when combined with radiation.

The paper identifies the pentose phosphate pathway's role in regulating radial glia cell fate during human cortical development using metabolic assays and genetic manipulations.

This study shows that combining radiation with forskolin induces a differentiation-like state in glioma cells, reducing proliferation and extending survival in mouse models.

This study creates a 3D histological cell atlas of the developing human brain, providing detailed cell counts, proliferative dynamics, and cell type distribution at 13-14 and 20-21 gestational weeks.

This study identifies a neurovascular progenitor cell type in glioblastoma that links distinct malignant lineages and influences tumor composition and survival.

This study shows that human-specific SRGAP2B/C paralogs drive neotenic microglia maturation and influence synaptic development in human brains.

The paper uses single-cell genomics to reconstruct developmental trajectories of 170 neuronal subtypes in the human hypothalamus across development.

This study shows glucose acts as a morphogen that modulates transcription factor dimerization during tissue differentiation.

The paper uses single-cell RNA-sequencing to identify dynamic molecular signatures during cortical arealization in the human brain, revealing gene expression patterns that define distinct cortical areas.

The paper develops a single-nuclei RNA sequencing approach to study MECP2 dysfunction in Rett Syndrome, identifying aberrant gene expression and a role for POU2F1/OCT1 in stress response.

The UCSC Cell Browser allows visualization of gene expression and metadata in single-cell datasets through a web interface and Python package.

Single-cell RNA sequencing of 289,000 first-trimester human brain cells identifies nine telencephalic progenitor subpopulations, a transient mesenchymal-like population, human-enriched C1orf61+ and ID4+ progenitors, and low early organoid fidelity.

This study maps the single-cell transcriptomic dynamics of hESC-RPE differentiation, identifies an intermediate progenitor, and shows in vivo maturation after transplantation.

The paper uses chimpanzee cerebral organoids to identify human-specific genes in cortical development and finds increased PI3K/AKT/mTOR activation in human outer radial glia.

This study identifies 99 genes associated with autism spectrum disorder through large-scale exome sequencing, showing differences in mutation frequencies between ASD and severe neurodevelopmental delay groups.

This study constructs a single-cell atlas of human glioblastoma, revealing a single axis of variation in tumor-propagating cells and linking mesenchymal GSCs to poor prognosis.