Anton M. Simeonov

Scalable Hypothalamic Arcuate Neuron Differentiation from Human Pluripotent Stem Cells Suitable for Modeling Metabolic and Reproductive Disorders

This paper describes a scalable method to differentiate human pluripotent stem cells into hypothalamic arcuate neurons, which can model metabolic and reproductive disorders.

Modeling Friedreich's ataxia with Bergmann glia-enriched human cerebellar organoids

This paper develops a human cerebellar organoid model that recapitulates cerebellar development and reveals disease-specific phenotypes in Friedreich's ataxia.

Breaking the Phalanx: Overcoming Bacterial Drug Resistance with Quorum Sensing Inhibitors that Enhance Therapeutic Activity of Antibiotics

This study identifies synergistic combinations of quorum-sensing inhibitors and antibiotics to combat antibiotic-resistant bacteria, finding that piperacillin with ketoprofen, indomethacin, and piroxicam shows broad antimicrobial action.

Directed Differentiation of Human Pluripotent Stem Cells into Radial Glia and Astrocytes Bypasses Neurogenesis

This paper develops a method to efficiently generate astrocytes from human pluripotent stem cells by bypassing neurogenesis, validated through multiple assays and adapted for drug modeling.

A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike

This paper develops potent humanized nanobodies against SARS-CoV-2 spike protein, showing effectiveness against the Alpha variant and providing structural insights into their neutralization mechanism.

Small Molecule Antiviral Compound Collection (SMACC): a database to support the discovery of broad-spectrum antiviral drug molecules.

The paper curates a database of antiviral compounds tested against 13 emerging viruses, identifies potential broad-spectrum antivirals, and highlights the need for coordinated research efforts.

Allosteric binders of ACE2 are promising anti-SARS-CoV-2 agents

The paper identifies five compounds that inhibit SARS-CoV-2 replication by binding to ACE2 without disrupting its enzymatic function, serving as potential acute treatments for COVID-19.

A Comprehensive Roadmap of Human Placental Development in vitro

This study develops methods to efficiently generate placental cell types from human pluripotent stem cells and validates their characteristics using multi-omics analyses.

Scalable Generation of Pseudo-Unipolar Sensory Neurons from Human Pluripotent Stem Cells

This paper describes a method to efficiently generate human sensory neurons from pluripotent stem cells for drug development.

Enhancing the Fitness of Embryoid Bodies and Organoids by Chemical Cytoprotection

This paper shows that using a small molecule cocktail called CEPT during cell aggregation improves the survival and quality of embryoid bodies and organoids derived from human pluripotent stem cells.

Genotype-phenotype correlation analysis and therapeutic development using a patient stem cell-derived disease model of Wolfram syndrome

This study uses a patient-derived stem cell model to show that a specific WFS1 variant causes mild Wolfram syndrome, which can be treated with chemical chaperones.

Discovery of TMPRSS2 inhibitors from virtual screening

This study identifies novel TMPRSS2 inhibitors through virtual screening and experimental validation, offering potential drug candidates for COVID-19 treatment.

Small Molecule Inhibitors of the Human Histone Lysine Methyltransferase NSD2 / WHSC1 / MMSET Identified from a Quantitative High-Throughput Screen with Nucleosome Substrate

This study identifies five small molecule inhibitors of NSD2 through high-throughput screening and validates their activity in cell-based assays.