Carlos A. Tristan

This paper describes a scalable method to differentiate human pluripotent stem cells into hypothalamic arcuate neurons, which can model metabolic and reproductive disorders.

This paper develops a human cerebellar organoid model that recapitulates cerebellar development and reveals disease-specific phenotypes in Friedreich's ataxia.

This study identifies nuclear GAPDH translocation as a mediator of stress-induced cardiac hypertrophy through BRG1-associated chromatin remodeling in mice and human patients.

This study shows that co-culturing human iPSC-derived sensory neurons with rodent satellite glia enhances their differentiation and maturation, leading to more mature phenotypes and improved disease modeling.

This paper develops a method to efficiently generate astrocytes from human pluripotent stem cells by bypassing neurogenesis, validated through multiple assays and adapted for drug modeling.

This study develops methods to efficiently generate placental cell types from human pluripotent stem cells and validates their characteristics using multi-omics analyses.

This paper describes a method to efficiently generate human sensory neurons from pluripotent stem cells for drug development.

This paper shows that using a small molecule cocktail called CEPT during cell aggregation improves the survival and quality of embryoid bodies and organoids derived from human pluripotent stem cells.

SEQUIN provides a web-based RNA-seq analysis tool with quality control, visualization, and differential expression analysis for various biological contexts.