Tade Souaiaia

This paper uses sibling data to infer genetic architecture of extreme trait values, distinguishing between polygenic and rare variant influences.

The paper identifies departures from polygenic architecture in the tails of complex traits, showing rare alleles are more prevalent and impactful in extreme trait values.

BridgePRS improves polygenic risk score accuracy in non-European populations by leveraging shared genetic effects across ancestries, outperforming existing methods in simulated and real data.

The paper identifies 528 AT-related transcripts in rhesus monkey CeL neurons, including PKCδ, and shows their projection to BSTLd, suggesting a primate circuit relevant to anxiety.

The paper identifies differentially expressed genes in schizophrenia-associated neural progenitor cells, implicating WNT5A signaling in schizophrenia etiology.

The paper deconvolves transcriptional networks in schizophrenia to identify TCF4 as a master regulator potentially dysregulated in the disease.

This study evaluates the performance of three scRNA-seq methods through controlled experiments, finding they reliably detect genes above 5-10 molecules with linear measurement transfer functions.