Hei Man Wu

This study identifies 118 new genetic loci associated with Alzheimer's disease across diverse ancestries and discovers 48 novel risk loci, including those enriched in neuronal cell types.

This paper uses sibling data to infer genetic architecture of extreme trait values, distinguishing between polygenic and rare variant influences.

The paper identifies departures from polygenic architecture in the tails of complex traits, showing rare alleles are more prevalent and impactful in extreme trait values.

This paper conducts a GWAS of subclinical obsessive-compulsive symptoms (OCS) in 33,943 individuals, finding polygenic risk and genetic overlap with OCD.