Hojoong Kwak

This study uses nascent RNA sequencing to infer genetic ancestry and shows ancestry-based stratification improves detection of transcriptional differences compared to self-identified race.

This study identifies BRG1-driven ferroptosis resistance as a mechanism of BTKi resistance in MCL and shows that BRG1 inhibition restores ferroptotic sensitivity and synergizes with BTKi.

The paper introduces a method combining nascent RNA sequencing and poly(A) tail length sequencing to comprehensively analyze RNA dynamics, including synthesis, processing, stability, and decay.

The paper investigates the dynamics of genome organization in transcription condensates and identifies FUS as a factor facilitating gene body export upon activation.

The paper develops and applies nascent RNA-seq methods to identify cell-type specific transcription programs in human blood cells and clinical samples.

The paper identifies two types of eRNA QTLs associated with enhancer function and reveals a bipartite enhancer architecture through population-scale eRNA analysis.

The paper demonstrates that PRO-seq can detect RNA dependent RNA polymerase activity in (+)ssRNA viruses and links it to host immune gene expression in human blood samples.

This study introduces ChRO-seq to map nascent transcription in glioblastoma and identifies enhancers and transcription factors driving GBM subtypes and clinical outcomes.