Qinghua Nie

The ChickenGTEx project provides a multi-tissue reference of regulatory variants in chicken, analyzing their functional impacts and utility in genetics, genomics, and evolutionary studies.

The paper introduces a large chicken reference panel with 13,187 genomes, showing improved imputation accuracy and statistical power for genome-wide association studies.

The paper identifies a circRNA-miRNA-mRNA axis in chicken myoblasts, showing circPLXNA2 promotes proliferation and inhibits apoptosis by modulating MDM4 expression.

This study constructs a chicken pan-genome from 20 de novo assemblies, identifying novel genes predominantly in sub-telomeric regions that are undetectable by DNA sequencing but present in transcriptomes.

The paper develops PETAL, a library of 62,208 mAbs against 15,199 peptides, enabling proteome-scale antibody generation and target discovery across species.