Author

Nicholas Williams

Wellcome Sanger InstituteORCID 0000-0003-3989-9167Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:clustering· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Alex CaganiD· 3 shared Emily MitchelliD· 3 shared Jyoti NangaliaiD· 3 shared Peter J. CampbelliD· 3 shared Daniel A. LeongamornlertiD· 2 shared David G. KentiD· 2 shared E. Joanna BaxteriD· 2 shared Elisa LaurentiiD· 2 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Alex CaganORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cell BiologyNature GeneticsPeer-reviewedJul 1, 2025

The long-term effects of chemotherapy on normal blood cells

Emily Mitchell, My H. Pham, Anna Clay…·Michael R. Stratton

This study examines the long-term effects of chemotherapy on normal blood cells by analyzing mutation burdens and cell population structure in treated individuals.

52 citationstop 1%

humanwhole-exome sequencing

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GenomicsNaturePeer-reviewedMar 5, 2025

Clonal dynamics and somatic evolution of haematopoiesis in mouse

Chiraag Deepak Kapadia, Nicholas Williams, Kevin J. Dawson…·Jyoti Nangalia

This study examines clonal dynamics and somatic evolution in mouse haematopoiesis, finding that stem cells accrue mutations at a rate similar to human progenitors and exhibit distinct age-related patterns.

40 citationstop 1%

mousewhole-genome sequencing

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GenomicsNaturePeer-reviewedJun 1, 2022

Clonal dynamics of haematopoiesis across the human lifespan

Emily Mitchell, Michael Spencer Chapman, Nicholas Williams…·Peter J. Campbell

This study tracks clonal dynamics in human haematopoiesis across age, finding that clonal diversity sharply declines after 70, driven by positive selection on many genes and loss of Y chromosome in males.

506 citationstop 1%

humanwhole-genome sequencing

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