Myriam P Hoyeck

This study shows that deleting both Casp1 and Ripk3 in mice improves glucose-stimulated insulin secretion, independent of cell death or inflammation.

This study investigates the role of β-cell-specific Ahr in metabolic responses to high-fat diet and pollutants, finding it critical for hyperinsulinemia and GLT-induced dysfunction.

This study shows cisplatin exposure worsens long-term metabolic issues in male, but not female, mice on a high-fat diet.

The paper generates and validates an AHR knockout human embryonic stem cell line to study AHR's role in islet development.

This study shows PFOS exposure dysregulates glucose-stimulated insulin secretion in multiple models, with effects varying by exposure duration and model system.

This study shows that CYP1A1/1A2 enzymes affect glucose homeostasis and insulin secretion in mice, with sex-specific differences in their impact on metabolic responses to high-fat diets.

This study shows cisplatin exposure impairs pancreatic islet function in male mice by disrupting insulin secretion and causing DNA damage in beta cells.

This study shows that AhR signaling in beta-cells mediates TCDD's effects on glucose homeostasis in both male and female mice.