Ma. Enrica Angela Ching

β-cell-specific Ahr expression is critical to high-fat diet-induced hyperinsulinemia

This study investigates the role of β-cell-specific Ahr in metabolic responses to high-fat diet and pollutants, finding it critical for hyperinsulinemia and GLT-induced dysfunction.

Cisplatin exposure alters long-term metabolic phenotype of male, but not female, high-fat diet-fed mice.

This study shows cisplatin exposure worsens long-term metabolic issues in male, but not female, mice on a high-fat diet.

Acute PFOS exposure consistently dysregulates glucose-stimulated insulin secretion across model systems

This study shows PFOS exposure dysregulates glucose-stimulated insulin secretion in multiple models, with effects varying by exposure duration and model system.

CYP1A1/1A2 enzymes mediate glucose homeostasis and insulin secretion in mice in a sex-specific manner

This study shows that CYP1A1/1A2 enzymes affect glucose homeostasis and insulin secretion in mice, with sex-specific differences in their impact on metabolic responses to high-fat diets.

Cisplatin exposure dysregulates pancreatic islet function in male mice

This study shows cisplatin exposure impairs pancreatic islet function in male mice by disrupting insulin secretion and causing DNA damage in beta cells.

The aryl hydrocarbon receptor in beta-cells mediates the effects of TCDD on glucose homeostasis in mice

This study shows that AhR signaling in beta-cells mediates TCDD's effects on glucose homeostasis in both male and female mice.