Jennifer E. Bruin

This study shows that deleting both Casp1 and Ripk3 in mice improves glucose-stimulated insulin secretion, independent of cell death or inflammation.

This study investigates the role of β-cell-specific Ahr in metabolic responses to high-fat diet and pollutants, finding it critical for hyperinsulinemia and GLT-induced dysfunction.

This study shows cisplatin exposure worsens long-term metabolic issues in male, but not female, mice on a high-fat diet.

The paper generates and validates an AHR knockout human embryonic stem cell line to study AHR's role in islet development.

This study shows PFOS exposure dysregulates glucose-stimulated insulin secretion in multiple models, with effects varying by exposure duration and model system.

This study shows that CYP1A1/1A2 enzymes affect glucose homeostasis and insulin secretion in mice, with sex-specific differences in their impact on metabolic responses to high-fat diets.

This study shows cisplatin exposure impairs pancreatic islet function in male mice by disrupting insulin secretion and causing DNA damage in beta cells.

This study investigates AHR-HIF1 pathway crosstalk in islet cells and finds hypoxia suppresses CYP1A1 and G6PC2 expression, with HIF1 dominating over AHR during TCDD + hypoxia co-treatment.

HumanIslets.com provides an open platform for accessing and analyzing human islet data, enabling research on diabetes through integrated molecular and cellular phenotyping.

This study shows that AhR signaling in beta-cells mediates TCDD's effects on glucose homeostasis in both male and female mice.