Ulrich Schwaneberg

This study engineers HPD variants with enhanced NTBC tolerance to restore tyrosine metabolism while maintaining catalytic activity and MHC-II binding properties.

This study uses directed evolution to identify amino acid substitutions that modulate HGD activity outside the catalytic pocket, revealing non-additive effects and structural impacts on enzyme function.

The paper introduces a test-tube directed evolution platform that enables high-throughput screening without specialized equipment, achieving significant enzyme improvement in catalytic efficiency.

This paper evolves a polyamidase through molecular dynamics simulations to improve its activity and stability for polyamide hydrolysis, but depolymerization remains limited.

This paper introduces a hybrid model that combines evolutionary probability and machine learning to improve protein engineering with limited data.