Author

Xue Geng

Georgetown UniversityORCID 0000-0003-4100-9899Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:spatial domain detection· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Adam NelsoniD· 1 shared Arielle Lutterman HeekeiD· 1 shared Candace Bavette MainoriD· 1 shared Claudine J. IsaacsiD· 1 shared Edward T. RichardsoniD· 1 shared Filipa C. LynceiD· 1 shared Geoffrey Ira ShapiroiD· 1 shared Hongkun Wang· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Adam NelsonORCID

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1 paper

Recent·Most cited

TALAVE in Breast Cancer: BRCA1/2 Mutation-Dependent Immune Remodeling after PARP Inhibition with Limited Checkpoint Engagement

Filipa C. Lynce, Kaoru Shimada, Claudine J. Isaacs, Xue Geng, Edward T. Richardson, Adam Nelson, Candace Bavette Mainor, Mei Wei, Julie Marie Collins, Paula Raffin Pohlmann, Arielle Lutterman Heeke, Kelly F Zheng, Madeline G Townsend, Nicole Swanson, Lauren M. Sloat, , Jennifer L. Guerriero

The paper shows BRCA-mutant breast cancers respond to PARP inhibitors with immune remodeling, but PD-L1 blockade is ineffective due to spatial separation of PD-L1+ cells and PD-1+ T cells.

bioRxiv · Sep 18, 2026 · PreprintCancer Biology