Sharmistha Dey

The paper constructs a large-scale LD and genotype imputation reference panel using whole-genome sequencing data from 2,680 Indian participants, improving imputation accuracy and polygenic risk score performance.

This study analyzes South Asian genomes to understand the evolutionary history of lactase persistence, finding that Steppe ancestry, not selection, explains most LP prevalence, with exceptions in two pastoralist groups.

The paper identifies AD-associated genes in South Asians using whole-genome sequence data and variant analysis, finding associations for APOE, PICALM, and TSPOAP1 with cognitive function.

This study analyzes 2,762 whole genome sequences from diverse Indian populations to reconstruct 50,000 years of evolutionary history, revealing major admixture events and archaic hominin gene flow.

The paper investigates neuroprotection via 5-LOX inhibition by peptide YWCS in SH-SY5Y cells exposed to Aβ25-35, showing activation of p73 and p53 isoforms and the PI3K/Akt pathway.

This study develops a sarcopenic mouse model and shows that physical activity improves muscle mass, stem cell function, mitochondrial capacity, and sestrin expression.