Yingye Fang

This study integrates angiogenic signaling data in obesity, revealing key changes in adipose vasculature and VEGF binding kinetics, providing parameters for systems biology modeling and therapeutic development.

The paper develops a computational model to study cross-family interactions between VEGF and PDGF ligands and their receptors, revealing key binding preferences and receptor density effects on ligand binding.

The paper quantifies plasma membrane and whole-cell RTK expression in cultured human endothelial cells from different organs, finding organ-specific distributions that may not fully reflect angiogenic capacities in vitro.

This study shows PDGFs activate VEGFRs and downstream pathways in endothelial cells, enhancing proliferation and migration, revealing cross-family signaling in angiogenesis.

This study identifies sex-specific differences in VEGF and PDGF ligand and receptor profiles in adipose tissue during obesity progression and weight loss using a mouse model.

This paper develops a mathematical model to predict OXT-OXTR binding dynamics in different cell types and genetic variants, showing how dosing strategies can be optimized for personalized medicine.