Silvia González-Nieves

The paper develops a computational model of VEGF-A signaling in lymphatic endothelial cells to predict junction state transitions and shows how obesity affects these dynamics in different LEC populations.

This study shows that loss of Ube4A in mice worsens experimental colitis by disrupting lipid metabolism and increasing inflammation.

This study investigates how insulin regulates lymphatic endothelial function through palmitoylation, identifying CD36 as a mediator of this process.

This study shows PDGFs activate VEGFRs and downstream pathways in endothelial cells, enhancing proliferation and migration, revealing cross-family signaling in angiogenesis.

This study identifies sex-specific differences in VEGF and PDGF ligand and receptor profiles in adipose tissue during obesity progression and weight loss using a mouse model.