Matthias Wielscher

This study identifies stiffness-dependent LOX regulation via HIF-1 in psoriasis, linking ECM modifications to disease progression through mechanosensitive fibroblasts.

This study identifies genetic loci associated with gestational duration and preterm delivery, showing maternal and fetal genetic effects and antagonistic pleiotropy with birth weight.

This study performs a multi-ancestry GWAS on lung function and COPD, identifying 559 genes and 29 pathways, and showing genetic risk scores are associated with COPD across ancestries.

The paper introduces methylSCOPA and META-methylSCOPA software for multi-phenotype epigenome-wide association studies, identifying significant methylation sites associated with fasting glucose and insulin levels.

This study expands the genetic landscape of COPD by identifying 82 risk loci, revealing associations with lung function, cell types, and comorbidities.

The paper identifies 279 new genetic signals for lung function across multiple ancestries, showing associations with COPD and pleiotropic effects.

The paper uses machine learning to predict glycaemic traits from multi-omics data in longitudinal cohorts, identifying key predictors like methylation marks and metabolic variables.

This study identifies a fetal genome-wide association signal near pro-inflammatory cytokine genes on 2q13 linked to gestational duration and preterm/postterm birth.