Marika Oksanen

The paper develops a transcriptomic-guided compound prioritization pipeline and validates it with proteomics, identifying two compounds that partially rescue HNRNPU deficiency phenotypes.

The paper investigates the molecular interactome of HNRNPU, revealing its role in neuronal differentiation and DNA methylation through integration of PPI, RNA targets, and methylation data.

The paper identifies trans-contacting intronic RNAs (TIRs) in neuronal cells that form nuclear scaffolds called introsomes, influencing 3D genome organization and gene expression.

This study shows that HNRNPU deficiency causes chromatin remodeling, transcriptional changes, and delayed neurogenesis in hindbrain-derived neural progenitors.

This study uses fractional factorial design to screen environmental factors on neural progenitors, identifying pathway-level changes linked to autism risk.

The paper identifies circRNAs from synaptic host genes in human neuronal differentiation and shows SFPQ regulates their expression.