Cancer BiologybioRxivPreprint
Identification and Characterization of Neoplastic Cells in Keratin-Positive Giant Cell-Rich Tumors
Maarten van der Linde, John S.A. Chrisinger, Elizabeth G. Demicco…·David G.P. van IJzendoorn
This paper uses single-nuclei RNA sequencing and spatial transcriptomics to characterize KPGCT, showing neoplastic cells express HMGA2::NCOR2 fusions and activate the hippo pathway, driving CSF1 production and macrophage recruitment.