Author

Shanthini Sockanathan

Johns Hopkins UniversityORCID 0000-0003-4147-4782Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Consuelo Jimenez-OrnelasiD· 1 shared Nan ZhangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

2 top collaborators · 0 mutual co-author links

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1 shared paperNeuroscience

Consuelo Jimenez-OrnelasORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 21, 2026

Region-dependent regulation of Tau phosphorylation by Glycerophosphodiester Phosphodiesterase 2 in a mouse model of tauopathy

Consuelo Jimenez-Ornelas, Shanthini Sockanathan

This study shows that GDE2 modulates Tau phosphorylation in a region-specific manner in a mouse tauopathy model, affecting kinase activity and Tau aggregation propensity.

DOI 10.64898/2026.09.14.751492

mouseproteomics

𝕏 PostBluesky

NeuroscienceScientific ReportsPeer-reviewedDec 11, 2025

Regulation of Glypican 6-mediated Wnt activation maintains TDP-43 nuclear localization in neurons

Nan Zhang, Shanthini Sockanathan

This study identifies a signaling axis involving GDE2, GPC6, and the Wnt pathway that regulates NPC integrity and TDP-43 nuclear localization in neurons.

4 citations

humanmouse

𝕏 PostBluesky