Fred A. Hamprecht

This study quantifies RBC shape recovery dynamics during Plasmodium falciparum infection, showing that parasite-induced membrane stiffening and knob architecture significantly affect relaxation time.

The paper identifies insecticides that affect both mosquito vectors and malaria parasites, demonstrating a scalable method to find compounds that kill mosquitoes and suppress parasite transmission.

BOMS improves cell segmentation in spatial transcriptomics by using mRNA spot locations and gene labels without auxiliary stains, achieving comparable performance to existing methods with faster execution.

The paper introduces computational tools for 3D nuclei segmentation and analysis, showing variations in nuclear-to-cell volume ratios across tissues.

The paper explores a spectrum of visualization methods between t-SNE and UMAP for single-cell data, showing how varying a single parameter affects the representation of local vs. continuous structures.

This paper reports the structure of yeast seipin, revealing a decameric cage that facilitates lipid droplet formation through conformational changes.

ISTDECO improves gene expression decoding in IST data by combining spot localization and barcode decoding into a single algorithm, achieving state-of-the-art performance in noisy and crowded conditions.