PBX1 and PBX3 transcription factors regulate SHH expression in the Frontonasal Ectodermal Zone through complementary mechanisms
Chan Hee Mok, Diane P. Hu, Marta Losa, Maurizio Risolino, Licia Selleri, Ralph Marcucio
The paper shows PBX1 and PBX3 regulate SHH expression in the FEZ through opposite mechanisms, with PBX1 upregulating and PBX3 downregulating SHH via a shared cis-regulatory element.
PLoS Genetics · May 21, 2025Peer-reviewedDevelopmental Biology