Marta Losa

The paper identifies a novel epithelial population, Zippering Lambda, whose cell cycle arrest is critical for facial prominence fusion and is disrupted in orofacial clefting.

The paper shows PBX1 and PBX3 regulate SHH expression in the FEZ through opposite mechanisms, with PBX1 upregulating and PBX3 downregulating SHH via a shared cis-regulatory element.

The paper identifies miR-92b-3p as a regulator of cardiovascular gene regulatory networks in mouse branchial arches, showing its role in downregulating cardiac transcription factors during development.

The paper reconstructs a gene regulatory network directed by PBX1/2 and HAND2 in mouse limb development, showing their genetic interaction and tissue-specific function.

The paper generates melanocytes from hPSCs through two distinct developmental trajectories and identifies T2-specific factors that promote melanoma metastasis.

The paper investigates how HOX paralogs interact with TALE TFs to generate tissue-specific enhancer activation patterns in mouse embryos.

The paper uses deep learning to identify tissue-specific TF binding sites by analyzing ChIP-seq data from MEIS and HOXA2 in mouse branchial arches.