Ralph Marcucio

The paper shows that reduced brain growth in ciliary transition zone mutants causes premature facial fusion by mechanically forcing facial prominences into convergence.

The paper analyzes 3D micro-CT images of chicken embryos to show that primary palatal fusion creates a structurally constrained shape window during craniofacial development.

The paper uses spatial proteomics to show age-related delays in fracture healing by analyzing extracellular matrix composition in young and aged mice.

This study shows that ultrafine-grained stainless steel implants reduce early Staphylococcus aureus biofilm formation in vitro and in mouse models.

The paper shows PBX1 and PBX3 regulate SHH expression in the FEZ through opposite mechanisms, with PBX1 upregulating and PBX3 downregulating SHH via a shared cis-regulatory element.

The paper inhibits three downstream RTK signaling pathways in chicken embryos and finds they cause similar truncation of the frontonasal process, suggesting interdependent roles in morphogenesis.

This study shows that CD47 inhibition impairs bone fracture healing by reducing mesenchymal stem cell proliferation, despite increased endothelial cell proliferation.

This study shows that Zmpste24-/- mice have delayed fracture healing with immune dysregulation and increased cellular senescence compared to wild-type mice.

The paper develops an imaging pipeline to quantify 3D cellular proliferation and morphology during mouse facial development, showing their tight correlation.

This study shows that reduced Fgf8 dosage causes asymmetric jaw development in mice, with left-side defects more severe than right-side, and links these asymmetries to heart development.

MusMorph provides standardized mouse morphology data for meta-analyses, including craniofacial and brain structures across developmental stages and genotypes.

The paper develops a process-centered multivariate genotype-phenotype approach to analyze craniofacial shape variation in mice, linking gene sets to shape axes and predicting phenotypic effects beyond shape.

This paper develops CNNs to segment tissues and proliferating cells in light-sheet microscopy images, achieving results comparable to manual segmentation.

This study identifies 37 QTL for facial shape in DO mice, finding enrichment for genes involved in skeletal and facial development, despite small individual effects.

This study shows that β-catenin signaling regulates chondrocyte-to-osteoblast transformation during fracture healing and identifies its role in stem cell generation for repair.