Diane P. Hu

A Novel Approach to Reducing Spinal Implant-Associated Infections

This study shows that ultrafine-grained stainless steel implants reduce early Staphylococcus aureus biofilm formation in vitro and in mouse models.

PBX1 and PBX3 transcription factors regulate SHH expression in the Frontonasal Ectodermal Zone through complementary mechanisms

The paper shows PBX1 and PBX3 regulate SHH expression in the FEZ through opposite mechanisms, with PBX1 upregulating and PBX3 downregulating SHH via a shared cis-regulatory element.

Downstream branches of receptor tyrosine kinase signaling act interdependently to shape the face

The paper inhibits three downstream RTK signaling pathways in chicken embryos and finds they cause similar truncation of the frontonasal process, suggesting interdependent roles in morphogenesis.

β-catenin Signaling Regulates Cell Fate Decisions at the Transition Zone of the Chondro-Osseous Junction During Fracture Healing

This study shows that β-catenin signaling regulates chondrocyte-to-osteoblast transformation during fracture healing and identifies its role in stem cell generation for repair.

Pairwise and Higher-Order Epistatic Interactions Have a Significant Impact on Bronchodilator Drug Response in African American Youth with Asthma