Pranjal Biswas

This study shows that sGC subunits act as Hsp90 co-chaperones to facilitate heme acquisition and functional maturation of apo-hemeproteins in mammalian cells.

The paper identifies FLVCR1b as the mitochondrial heme exporter that delivers heme to GAPDH and downstream hemeproteins in human cells.

The paper visualizes mitochondrial heme flow through GAPDH to IDO1 in living cells and shows NO regulates heme reallocation between GAPDH and IDO1 based on NO levels.