BiophysicsNature CommunicationsPeer-reviewed
Extracellular K+ modulates the pore conformations of Cys-loop receptor anion channels
Takushi Shimomura, Yoshihiro Kubo, Minoru Saitoe, Yoshikatsu Suzuki
This study identifies an extracellular K+ binding site in Cys-loop receptors that modulates pore conformations and Cl- conductance, with similar mechanisms observed in a human glycine receptor variant.
DOI 10.1038/s41467-026-71629-z