Author

James Castelli‐Gair Hombría

Centro Andaluz de Biología del DesarrolloORCID 0000-0003-4183-5250Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 3

Signature Assays, Organisms & Methods

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Organism:Drosophila· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Carlos Sánchez-HiguerasiD· 2 shared Mar García-FerrésiD· 2 shared Sol SotillosiD· 2 shared Anna Biason‐LauberiD· 1 shared Ávaro Marrufo-Mena· 1 shared Daniel Barcenilla-Merino· 1 shared Daniel RodrígueziD· 1 shared Dmytro SirokhaiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersDevelopmental Biology

Carlos Sánchez-HiguerasORCID

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3 papers

Recent·Most cited

Developmental BiologybioRxivPreprintOct 2, 2026

Shade enhancers, a class of redundant enhancers uncovered by functional JAK-STAT pathway dissection

Carlos Sánchez-Higueras, Laura Terrón‐González, Daniel Barcenilla-Merino…·James Castelli‐Gair Hombría

The paper identifies a new class of redundant enhancers, called shade enhancers, that mediate identical developmental functions despite driving different expression patterns.

DOI 10.64898/2026.09.28.754901

Drosophilaexperimental assay

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Developmental BiologyeLifePeer-reviewedNov 3, 2022

DLC3/Cv-c function in testis development in humans and Drosophila: implication for variants of sex development

Sol Sotillos, Isabel von der Decken, Ivan Domenech Mercadé…·James Castelli‐Gair Hombría

The paper shows DLC3/Cv-c is essential for testis development in humans and Drosophila, with the StART domain mediating function independent of the GAP domain.

6 citations

humanDrosophila

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Developmental BiologyPLoS GeneticsPeer-reviewedOct 3, 2022

Specification of the endocrine primordia controlling insect moulting and metamorphosis by the JAK/STAT signalling pathway

Mar García-Ferrés, Carlos Sánchez-Higueras, José Manuel Espinosa, James Castelli‐Gair Hombría

The paper identifies the JAK/STAT pathway as central to the specification of insect endocrine glands, showing shared upstream regulators with tracheal development.

5 citations

statistical modelgene regulatory network inference

𝕏 PostBluesky