Author

Ivan Domenech Mercadé

AstraZeneca (United Kingdom)ORCID 0000-0003-2115-8475Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Organism:Drosophila· 1 Organism:human· 1

Frequent Co-Authors

Anna Biason‐LauberiD· 1 shared Catarina FrancoiD· 1 shared Cristina Sayago Ferreira· 1 shared Daniel RodrígueziD· 1 shared Diane HattoniD· 1 shared Dmytro SirokhaiD· 1 shared Elizabeth A. MilleriD· 1 shared Giulia LambiaseiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperDevelopmental Biology

Anna Biason‐LauberORCID

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2 papers

Recent·Most cited

Identification of Cellular Signatures Associated with Chinese Hamster Ovary (CHO) Cell Adaptation for Secretion of Antibodies

Ying Bai, Ivan Domenech Mercadé, Ramy Elgendy, Giulia Lambiase, Sew‐Yeu Peak‐Chew, Catarina Franco, Steven W. Wingett, Tim J. Stevens, Luigi Grassi, Noah Hitchcock, Cristina Sayago Ferreira, Diane Hatton, Elizabeth A. Miller, Rajesh K. Mistry

This study identifies cellular adaptations in CHO cells linked to antibody production, finding that transgene copy number and mRNA expression levels are key factors in productivity.

Computational and Structural Biotechnology Journal · Dec 10, 2024Peer-reviewedBioengineering

DLC3/Cv-c function in testis development in humans and Drosophila: implication for variants of sex development

Sol Sotillos, Isabel von der Decken, Ivan Domenech Mercadé, Sriraksha Srinivasan, Dmytro Sirokha, Л. А. Лившиц, Stefano Vanni, Serge Nef, Anna Biason‐Lauber, Daniel Rodríguez, James Castelli‐Gair Hombría

The paper shows DLC3/Cv-c is essential for testis development in humans and Drosophila, with the StART domain mediating function independent of the GAP domain.

eLife · Nov 3, 2022Peer-reviewedDevelopmental Biology