PARP inhibitor synthetic lethality reveals homologous recombination sub-pathway architecture
Ki Choi Chan, Anastasiia Kovina, Johanna Ertl da Costa, Anke Busch, Ratna Nuria Cordoni, Björn Stratenwerth, Markus Löbrich
This study uses CRISPR screening to map genetic interactions in homologous recombination sub-pathways, revealing roles of RAD54L, RAD51AP1, RAD54B, and TOP3A in pathway choice and function.
bioRxiv · Mar 7, 2026 · PreprintMolecular Biology