Markus Löbrich

This study compares DNA double-strand break repair efficiency at low and high damage levels between childhood cancer survivors and cancer-free individuals, finding that survivors repair low-level breaks more efficiently.

This paper defines the role of RAD54B in homologous recombination using cryo-EM and biochemical assays, showing it stabilizes RAD51 filaments and promotes D-loop formation.

This study uses CRISPR screening to map genetic interactions in homologous recombination sub-pathways, revealing roles of RAD54L, RAD51AP1, RAD54B, and TOP3A in pathway choice and function.

This study shows that Nek1 regulates Rad54 phosphorylation at Ser572 to promote HR in adult mice but not in embryos, with Nek3 and Nek5 compensating in embryonic cells.