Author

Johanna Ertl da Costa

Technische Universität DarmstadtORCID 0009-0001-4137-3642Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:structural biology· 1

Frequent Co-Authors

Markus LöbrichiD· 2 shared Anastasiia KovinaiD· 1 shared Anke BuschiD· 1 shared Bilge ArgunhaniD· 1 shared Björn Stratenwerth· 1 shared Elizabeth A. McCormack· 1 shared Ki Choi ChaniD· 1 shared Lucas KuhleniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Markus LöbrichORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMar 24, 2026

Structures and molecular mechanisms of RAD54B in modulating homologous recombination

Pengtao Liang, Stephanie Tye, Johanna Ertl da Costa…·Xiaodong Zhang

This paper defines the role of RAD54B in homologous recombination using cryo-EM and biochemical assays, showing it stabilizes RAD51 filaments and promotes D-loop formation.

DOI 10.64898/2026.03.22.713441

humanstructural biology

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Molecular BiologybioRxivPreprintMar 7, 2026

PARP inhibitor synthetic lethality reveals homologous recombination sub-pathway architecture

Ki Choi Chan, Anastasiia Kovina, Johanna Ertl da Costa…·Markus Löbrich

This study uses CRISPR screening to map genetic interactions in homologous recombination sub-pathways, revealing roles of RAD54L, RAD51AP1, RAD54B, and TOP3A in pathway choice and function.

DOI 10.64898/2026.03.06.709881

humanexperimental assay

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