Merel Kuijs

This study shows TNF-α disrupts the malate-aspartate shuttle in iPSC-derived enteric neural cells from PD patients, causing metabolic shifts and mitochondrial dysfunction, which can be reversed by targeting glutamate metabolism.

GraphCompass provides graph analysis methods to compare cell spatial organization across conditions using spatial omics data.

This paper creates a human endoderm organoid cell atlas by integrating single-cell transcriptomes from multiple organoid types to compare cell states with primary tissues and disease models.