Author

Arne Gessner

Friedrich-Alexander-Universität Erlangen-NürnbergORCID 0000-0002-1729-4231Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Aiden HaghikiaiD· 1 shared Anne HartebrodtiD· 1 shared Beate WinneriD· 1 shared Bruno GhirottoiD· 1 shared Cezmi A. AkdişiD· 1 shared Christina JamesiD· 1 shared Claudia GüntheriD· 1 shared Daniele MauroiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperImmunology

Aiden HaghikiaORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

TNF-α disrupts the malate-aspartate shuttle, driving metabolic rewiring in iPSC-derived enteric neural lineages from Parkinson's Disease patients

Bruno Ghirotto, Luís Eduardo Gonçalves, Vivien Ruder, Christina James, Elizaveta M. Gerasimova, Tania Rizo, Holger Wend, Michaela Farrell, Juan Gerez, Natalia Cecilia Prymaczok, Merel Kuijs, Maiia Shulman, Anne Hartebrodt, Iryna Prots, Arne Gessner, , Beate Winner

This study shows TNF-α disrupts the malate-aspartate shuttle in iPSC-derived enteric neural cells from PD patients, causing metabolic shifts and mitochondrial dysfunction, which can be reversed by targeting glutamate metabolism.

Nature Communications · Apr 1, 2026Peer-reviewedNeuroscience

Gut-specific H3R signaling orchestrates microglia-dependent resolution of peripheral inflammation

Kerstin Dürholz, Leona Ehnes, Mathias Linnerbauer, Eva Schmid, Heike Danzer, Michael Hinzpeter-Schmidt, Lena Lößlein, Lena Amend, Michael Frech, Vugar Azizov, Fabian Schälter, Arne Gessner, Sébastien Lucas, Till-Robin Lesker, Regina Verena Taudte, , Mario M. Zaiss

The paper identifies gut microbiota-derived histamine as a factor enabling the CNS to suppress peripheral inflammation in RA by activating H3R in the intestine and modulating microglia.

Journal of Clinical Investigation · Jul 10, 2025Peer-reviewedImmunology