Bradley Walters Biggs

The paper introduces a Bayesian Personalized Ranking model to predict microbial substrate preferences and develops an agent that integrates this model with a growth model and LLM for autonomous microbial analysis.

The paper introduces Coaux-Seq, a method using DNA barcoded fragment libraries and auxotroph complementation to characterize protein function in bacteria, identifying 53 previously unvalidated proteins.

This paper engineers DNA polymerase activity to respond to Ca2+ by modifying the Pol δ complex in yeast, enabling Ca2+-dependent biosensing.

This study demonstrates the use of Acinetobacter baylyi ADP1 to convert lignin-derived aromatic monomers into valuable natural products through genetic engineering and metabolic pathway optimization.

This paper develops genetic tools for Acinetobacter baylyi ADP1 to enhance its use in sustainable chemical manufacturing and lignin bioprocessing.

The paper introduces a new gene expression cassette called a riboregulated switchable feedback promoter (rSFP) to dynamically control gene expression in metabolic engineering, achieving higher titers in a Taxol precursor biosynthesis pathway.