John Tyler Lazar

This paper develops a cell-free biosynthesis system for 1,2,4-butanetriol, achieving high productivity and yield at scale while reducing costs.

The paper uses machine learning to guide cell-free expression of carbonic anhydrases, identifying variants with improved stability under high temperatures.

This study uses optogenetic control to manipulate gut bacterial metabolism in C. elegans and shows that increased colanic acid production extends lifespan.

The paper introduces a new gene expression cassette called a riboregulated switchable feedback promoter (rSFP) to dynamically control gene expression in metabolic engineering, achieving higher titers in a Taxol precursor biosynthesis pathway.