Robert V. Skibbens

The paper shows that aberrant cohesin function in yeast leads to Mcd1 degradation via E3 ligases, promoting cell lethality through a negative feedback mechanism.

The paper identifies transcription factors and regulatory mechanisms that influence Mcd1 levels in eco1 rad61 yeast mutants, affecting cell growth.

This study identifies a mechanism linking Esco2 and cohesin to thalidomide-induced teratogenicity, unifying Cornelia de Lange syndrome and Roberts syndrome.

This study shows that PCNA affects genomic stability by modulating cohesin levels and acetylation, and that its misregulation can lead to genome instability in cohesin mutant cells.