Arthur Gouhier

The paper shows PAX7 acts in two chromatin compartments, with distinct mechanisms and biological outcomes during pituitary development.

This study identifies the sequence of events by which the pioneer factor Pax7 initiates chromatin opening through cell-cycle dependent mechanisms.

This study investigates the structural requirements of Pax7 for chromatin interaction and opening, showing that specific isoforms and C-terminal domains are essential for its pioneer factor function.

This study shows that Pax7's pioneer action on heterochromatin requires both DNA binding domains, while low affinity binding only needs the paired domain.