Author

Kazuhiko Kume

Nagoya City UniversityORCID 0000-0003-4232-1657Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2 Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:Drosophila· 2 Approach:experimental assay· 2 Research Focus:GWAS / association mapping· 2 Organism:human· 2 Approach:statistical model· 2 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Jun TomitaiD· 2 shared Makoto HondaiD· 2 shared Takashi KanbayashiiD· 2 shared Yoshiaki S. KatoiD· 2 shared Aditya AmbatiiD· 1 shared Akiko HidaiD· 1 shared Andrea N. Goldstein‐PiekarskiiD· 1 shared Anne Marie Landtblom· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Jun TomitaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Polygenic risk scores and Mendelian randomization reveal circadian genetic contributions to idiopathic hypersomnia

Taku Miyagawa, Mihoko Shimada, Kotomi Tanida, Nozomu Kotorii, Takao Kato, Tatayu Kotorii, Yu Ariyoshi, Hiroshi Hiejima, Motohiro Ozone, Naohisa Uchimura, Azusa Ikegami, Kazuhiko Kume, Takashi Kanbayashi, Aya Imanishi, Yuichi Kamei, , Makoto Honda

The paper uses polygenic risk scores and Mendelian randomization to show circadian genetic factors contribute to idiopathic hypersomnia.

medRxiv · Jan 6, 2026 · PreprintGenetic & Genomic Medicine

Interneurons of fan-shaped body promote arousal in Drosophila

Yoshiaki S. Kato, Jun Tomita, Kazuhiko Kume

The paper identifies a novel sleep-regulatory circuit in Drosophila involving pontine neurons that promote arousal and connect to sleep-promoting dFB neurons.

PLoS ONE · Nov 21, 2022Peer-reviewedNeuroscience

Protocerebral bridge neurons that regulate sleep in Drosophila melanogaster

Jun Tomita, Gosuke Ban, Yoshiaki S. Kato, Kazuhiko Kume

The paper identifies a sleep-regulating neuronal circuit in the protocerebral bridge of Drosophila involving interactions between interneurons and dopaminergic neurons.

Frontiers in Neuroscience · Oct 15, 2021Peer-reviewedNeuroscience

Kleine Levin syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci.

Aditya Ambati, Ryan P. Hillary, Smaranda Leu‐Semenescu, Hanna Maria Ollila, Ling Lin, Emmanuel During, Neal M. Farber, Thomas J Rico, Juliette H. Faraco, Eileen B. Leary, Andrea N. Goldstein‐Piekarski, Yu‐Shu Huang, Fang Han, Yakov Sivan, Michel Lecendreux, , Emmanuel Jean-Marie Mignot

This study identifies a genetic association between Kleine-Levin Syndrome and variants in the TRANK1 gene, with increased risk linked to birth difficulties.

Proceedings of the National Academy of Sciences · Mar 18, 2021Peer-reviewedGenetic & Genomic Medicine